WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Fatty acid metabolism       ID:00071
C=43; O=6; E=0.03; R=214.92; rawP=2.53e-13; adjP=3.29e-12
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
2  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
3  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
4  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
5  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
6  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315


Database:KEGG pathway       Name:PPAR signaling pathway       ID:03320
C=70; O=5; E=0.05; R=110.02; rawP=9.30e-10; adjP=6.04e-09
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000134824 NA FADS2 fatty acid desaturase 2 9415 ENSG00000134824
2  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
3  ENSG00000110090 NA CPT1A carnitine palmitoyltransferase 1A (liver) 1374 ENSG00000110090
4  ENSG00000157184 NA CPT2 carnitine palmitoyltransferase 2 1376 ENSG00000157184
5  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240


Database:KEGG pathway       Name:Fatty acid elongation in mitochondria       ID:00062
C=8; O=3; E=0.01; R=577.59; rawP=1.37e-08; adjP=5.94e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
2  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
3  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315


Database:KEGG pathway       Name:Valine, leucine and isoleucine degradation       ID:00280
C=44; O=4; E=0.03; R=140.02; rawP=1.89e-08; adjP=6.14e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
2  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240
3  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
4  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315


Database:KEGG pathway       Name:Peroxisome       ID:04146
C=79; O=4; E=0.05; R=77.99; rawP=2.06e-07; adjP=5.36e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
2  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
3  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
4  ENSG00000166821 NA PEX11A peroxisomal biogenesis factor 11 alpha 8800 ENSG00000166821


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=7; E=0.73; R=9.54; rawP=6.09e-06; adjP=1.32e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
2  ENSG00000121691 NA CAT catalase 847 ENSG00000121691
3  ENSG00000151726 NA ACSL1 acyl-CoA synthetase long-chain family member 1 2180 ENSG00000151726
4  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
5  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240
6  ENSG00000138029 NA HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 3032 ENSG00000138029
7  ENSG00000167315 NA ACAA2 acetyl-CoA acyltransferase 2 10449 ENSG00000167315


Database:KEGG pathway       Name:Biosynthesis of unsaturated fatty acids       ID:01040
C=21; O=2; E=0.01; R=146.69; rawP=8.47e-05; adjP=0.0001
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000134824 NA FADS2 fatty acid desaturase 2 9415 ENSG00000134824
2  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754


Database:KEGG pathway       Name:beta-Alanine metabolism       ID:00410
C=22; O=2; E=0.01; R=140.02; rawP=9.31e-05; adjP=0.0001
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000103150 NA MLYCD malonyl-CoA decarboxylase 23417 ENSG00000103150
2  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754


Database:KEGG pathway       Name:Insulin signaling pathway       ID:04910
C=138; O=3; E=0.09; R=33.48; rawP=9.90e-05; adjP=0.0001
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000132825 NA PPP1R3D protein phosphatase 1, regulatory subunit 3D 5509 ENSG00000132825
2  ENSG00000044446 NA PHKA2 phosphorylase kinase, alpha 2 (liver) 5256 ENSG00000044446
3  ENSG00000072310 NA SREBF1 sterol regulatory element binding transcription factor 1 6720 ENSG00000072310


Database:KEGG pathway       Name:Butanoate metabolism       ID:00650
C=30; O=2; E=0.02; R=102.68; rawP=0.0002; adjP=0.0002
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000084754 NA HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3030 ENSG00000084754
2  ENSG00000134240 NA HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 3158 ENSG00000134240




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).